The panel, from the church of San Francesco, Fabriano, is signed and dated in Latin on the plaque below: "CAROLVS CRIVELLVS VENETUS MILES PINXIT MCCCCLXXXXIII." The reprsented figures are Sts George, John the Baptist, Catherine of Alexandria, Venantius, Francis, Sebastian and angel musicians.
A document ordering the work on February 9, 1493 has been preserved. The altarpiece included the Pietà, and a predella that is now divided among the Castel Sant'Angelo in Rome, the Musée Jacquemart-André, Paris, and the Christian Museum at Esztergom.
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