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Domenico di Bartolo's major surviving achievement is his participation in a series of frescoes in the Pellegrinaio, the hall for pilgrims at Siena's Hospital of Santa Maria della Scala. The Frescoes have unusual secular subjects, which deal with the charitable, civic, and medical activities of the hospital. The Gothic vaulting of the room determined the arched openings. The settings are sometimes the rooms of the hospital itself. In their naturalism and their wealth of imagery drawn from contemporary life, these frescoes provide remarkable insight into Sienese activities.
In the six bays of the hall, two frescoes on the east wall (The Enlargement of the Hospital; Extension of Privileges by Celestine III), and four on the north wall (Feeding of the Poor; Raising and Marrying of Orphans; Reception of Pilgrims and Distribution of Alms; Caring for the Sick) were executed by Domenico di Bartolo.
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