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This altarpiece was intended for the chapel of Angelo Tezi in the church of Sant'Agostino in Perugia. The Virgin is enthroned on clouds with the Christ Child, whose right hand is raised in blessing. On the Virgin's right is the Augustian hermit Nicholas of Tolentino, and on her left is the Franciscan monk St Bernard of Siena. Kneeling in adoration below are St Sebastian and, on the left, St Jerome, a figure very similar to the St Jerome in Raphael's London Crucifixion.
The painting was executed with the collaboration of Eusebio da San Giorgio (c. 1478-after 1535 in Perugia) who was a pupil of Fiorenzo di Lorenzo.
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