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Sanchez Coello devoted himself to portrait painting, thanks to him we are now familiar with the figures of Philip II, Isabel Carla Eugenia, Catalina Micaela, and the unfortunate Prince Carlos.
This painting represents the daughters of Philip II and his third wife, Isabelle Valois. They were born in 1566 and 1567, respectively. Isabel Clara Eugenia later married Albert of Austria and as the Regent of Flandres she became the patroness of Rubens.
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