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The picture presents a view of the Chapel of San Brizio from the entry toward the altar wall and the vaulting. On the side walls, the preaching and deeds of the Antichrist and the joys of the chosen in paradise (left), the resurrection of the flesh and the tortures of the damned in hell (right) can be seen. In the first bay of the vaulting, painted by Signorelli, are virgins, patriarchs, martyrs, and Church fathers.
The side walls are covered with seven large scenes:
the Sermon and Deeds of the Antichrist,
the Destruction of the World,
the Resurrection of the Flesh,
the Damned,
the Elect,
the Paradise,
the Hell.
The ceiling frescoes (the groups of Apostles, Angels, Patriarchs, Doctors of the Church, Martyrs and Virgins) had been devised by Fra Angelico. The lower part of the walls is decorated with grotesque patterns and with busts of philosophers and poets alongside monochromes commenting their works, as well as illustrations from the Divine Comedy. The overall decoration is completed in the jambs of the windows and in the small chapel on the far wall by the figures of Archangels Raphael (with Tobias), Gabriel and Michael (weighing souls and subjugating the devil), by Bishop Saints Brizio and Constant, and the Lamentation over the Dead Christ with Saints Parenzo and Faustino.
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