This is the last scene, related to the imprisoned saint on the opposite wall. The episode is recounted in the Acts of the Apostles (12: 1-6). The scene shows Peter being awoken by the Angel and taken out of his cell, while the guard is sound asleep and notices nothing. Here too, the architecture is connected with that of the adjacent depiction. The sword-armed guard sleeps in the foreground, leaning on a stick, whilst the miraculous rescue is happening – this implies Christian salvation.

The fresco was originally attributed, along with all the others, to Masaccio. It was in 1838 when the first scholar attributed it to Filippino Lippi and this theory was accepted by all later critics.