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The altarpiece was executed for the church of San Procolo in Florence during Ambrogio's second and prolonged sojourn in Florence. Ambrogio was registered since 1327 in the Guild of Physicians and Apothecaries to which the painters also belonged.
The altarpiece is a dismembered triptych representing the Madonna and Child on the centre and St Nicholas of Bari and St Proculus at the sides. Originally it had a predella, too.
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