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The scene described in this painting was inspired by Ariosto's Orlando Furioso (Canto 19, 20-36), an epic poem published in 1516 and an inexhaustible source of subjects for painting. Here the figures of Angelica and Medoro are presented as a treatment of the Pietà in 'chivalric' mode,
This painting is an early example in the artist's career of a synthesis between his Venetian experience and the impact of Lombard realism.
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