In the 1480s Civitali and his workshop worked on many projects, the most important of which were the altar tomb of St Regulus and the chapel of the Volto Santo. The St Regulus monument is based on the tomb of Anti-pope John XXIII (c. 1425; Baptistery, Florence) by Donatello and Michelozzo; it includes some of Civitali's most ambitious carving, for example three life-size marble figures of saints and a delicately carved frieze that recalls the relief styles of Desiderio da Settignano and Jacopo della Quercia.
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