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This panel, showing the influence of the Sienese school, depicts the Virgin and Child enthroned, flanked by St Catherine of Alexandria, St Veronica, St Mustiola and St Lucy. The little-known St Mustiola was the patron saint of Chiusi, an Umbrian town only fifty kilometres from Orvieto and Perugia. Her inclusion in the present work perhaps indicates that the panel was commissioned by a patron from Chiusi.
The present work is a rare signed example by Cola. He signs his name COLA DE URBIUETERI, 'Urbiueteri' being the Latin name for the town of Orvieto, providing us with primary evidence of Cola's origin.
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