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The current building was built on the foundations of the pre-existing church of Sant'Andrea de Aquarizariis in 1482, commissioned by Pope Sixtus IV. The author of the original design is not known. In 1656-67 Pope Alexander VII had the edifice restored by Pietro da Cortona, who also added the famous Baroque façade. The interior has a short nave with cruciform vaulting and a tribune surmounted by a cupola. Cortona articulated the interior of the dome with octagonal coffering and a series of ribs radiating from the lantern.
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