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An early work by Isaia is the tomb of Antonio Martínez Chaves, the Cardinal of Portugal, originally in San Giovanni in Laterano, Rome. The commission for the tomb was initially given to Filarete; Isaia had apparently not yet completed it in 1449, when Filarete attempted to return to Rome to reclaim the commission. The sculptures from the dismantled tomb are incorporated in two monuments, a Baroque resetting of the Chaves tomb and the tomb of Cardinal Giulio Acquaviva (d 1574), both in San Giovanni in Laterano.
The original Chaves tomb can be reconstructed from a drawing. The effigy and half-length figures in the centre are flanked by standing allegories in niches. Prudence, now belonging to the tomb of Cardinal Giulio Acquaviva, was one of the standing allegories of the Chaves tomb.
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