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Jerome appears in the upper left as a penitent kneeling before a crucifix and beating his breast with a stone.
The landscape with tree-topped boulders on the left of the painting is clearly inspired by Dürer's engravings, and it contrasts with the panoramic vista on the right. The landscape throughout features symbolic motifs - woodcutter, shepherd and his flocks, and donkey beaten by its owner. The prominent cylindrical building in the background has been recognised as the Castel Sant'Angelo which serves to identify the city as Rome.
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