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The polyptych's central panel depicts the Madonna and Child with St Anne and is flanked by four wings showing Sts Catherine of Alexandria, John the Baptist, Anthony Abbot and Agnes. Originally, the pinnacle to the central Madonna and Child was a Blessing Christ, but it was detached by the middle of the 19th century and replaced with a representation of St Andrew from an unrelated altarpiece. The lateral saints, meanwhile, have retained their original pinnacles, each depicting one of the evangelists.
The polyptych was executed for the church of Santa Mustiola alla Rosa, Siena.
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