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This text of this manuscript is the Grammatica by Aelius Donatus (active mid 4th century), a Roman grammarian and teacher of rhetoric, the tutor of St. Jerome. It contains grammatical and moral treatises giving elementary instruction in verse. It was made for Massimiliano, the son of Ludovico Sforza (Ludovico il Moro), Duke of Milan (1452-1508) and his wife Beatrice d'Este. The illustrations were executed by several artists, including Ambrogio de Predis and Giovanni Pietro Birago.
On folio 1v Ambrogio de Predis painted a profile portrait of the young Massimiliano Sforza (1493-1530). Massimiliano later became Duke of Milan and ruled from 1512 to 1515, between the occupations of Louis XII of France (1500–1512), and Francis I of France in 1515.
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