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The vision of the Cross appeared to Constantine in the sky on the eve of a battle, with the words, "In this sign thou shalt conquer," a prophecy that was to prove true the next day when Constantine was victorious at Pons Milvius.
The enthroned Pope Clement I at the right bears the features of Leo X which connects the prophecy from the early Christian past to the present world of the pope who commissioned the painting.
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