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The present altarpiece was commissioned from the artist by the notary Ser Andrea di Cristofano Nacchianti for the family chapel in the church of San Simone, Florence, on 2 August 1503. It was possibly removed as a consequence of the flood of the Arno in 1557.
The saints represented in the painting are Mary Magdalene, Andrew, John the Baptist and Francis. The commission stipulated the depiction of angels collecting Christ's blood in chalice.
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