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The painting represents the painter's studio in Rome in which he has depicted himself three times. On the bottom left in the foreground, he sits on a low stool and holds up a second self-portrait showing him as a young man. The figure shown from back at the easel is also the painter. Hung on the walls and supported on easels there are twenty-five paintings interspersed with small-scale plaster casts of significant artworks on pedestals and pieces of furniture.
A fourth self-portrait was discovered in 1968 on the reverse of the canvas.
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