Guigone de Salins, the devout and respected wife of Nicolas Rolin, has left her mark throughout the Hospices. She was said to be "gentle, gracious and devoted to her husband".

Enamelled tiles, made at the Chancellor's behest, depict the spouses' initials joined by an oak branch and surrounded by a garland inscribed with a star and the word "SEULLE "(only). Triply symbolic : Guigone was the "only" woman in Nicolas' thoughts and heart and the guiding light in his life; the oak branch symbolizes their affection and fidelity.

Upon the death of her husband in 1461, Guigone renounced her rank and the honours that accompanied it to devote herself entirely to life in the Hospices until her death in 1469.

She is buried in the chapel in the Great Hall.