This work was executed under the influence of the art of Giotto and the overall mood is one of great solemnity. The presence of collaborators is unmistakable, and it was suggested that only the figure of the Madonna is actually by Simone.

Preview	Picture Data	Info
	Orvieto Polyptych c. 1321 Tempera on wood, 113 x 257 Museo dell'Opera del Duomo, Orvieto
	Orvieto Polyptych (detail) c. 1321 Tempera on wood, 94 x 48,5 cm Museo dell'Opera del Duomo, Orvieto
	Orvieto Polyptych (detail) c. 1321 Tempera on wood, 94 x 48,5 cm Museo dell'Opera del Duomo, Orvieto
	Boston Polyptych 1321-25 Tempera on wood, 235 x 405 cm Isabella Stewart Gardner Museum, Boston
	Boston Polyptych (detail) 1321-25 Tempera on wood, 137 x 102 cm Isabella Stewart Gardner Museum, Boston
	Madonna and Child with Angels and the Saviour 1320 Tempera on wood, 165 x 57 cm Museo dell'Opera del Duomo, Orvieto
	St Catherine and St Lucy 1320-25 Tempera on wood, 54 x 41 and 51 x 40 cm Berenson Collection, Settignano
	Madonna and Child (from Castiglione d'Orcia) 1320-25 Tempera on wood Pinacoteca Nazionale, Siena
	Madonna and Child (from Lucignano d'Arbia) 1321 Tempera on wood, 88 x 51 cm Pinacoteca Nazionale, Siena
	Crucifix 1321-25 Tempera on wood, 164 x 147 cm Church of Misericordia, San Casciano (Florence)