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The upper relief shows the deposition of Christ. It is horizontal, framed by curtains drawn back by two putti to reveal Christ. There are references to antique sculpture, from the scenes of mourning over the dead Meleager to representations of maenads with raised arms The position of the relief on the attic of the ciborium recalls Roman triumphal arches.
The image of the Virgin in the centre, the Madonna della Febbre, is attributed to Lippo Memmi. The ciborium is now in the Treasury of the Cappella della Sagrestia dei Beneficiati in St Peter's.
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