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During his journey to Zeeland, Dürer contracted a malaria-like infection from which he would never recover. This is the context within which this small drawing, a self-portrait, was presumably created, for the artist is pointing to a painful spot. The inscribed comment, "Do der gelb fleck ist und mit dem finger drawff do ist mir we" (This is the yellow spot and when I press my finger on it, it hurts) suggests that the sketch was intended to be sent to a non-local doctor for his diagnosis.
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