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The altarpiece was executed with the contribution of Callisto's brothers Scipione and Cesare, for the church of Santissima Trinità, Crema. The church belonged to a confraternity founded after a serious outbreak of the plague in the city of Crema, and dedicated to Sts Roch and Sebastian, the patron saints of those afflicted by pestilence. The represented saints on the altarpiece are Joseph, Peter, Paul, Roch, and Sebastian.
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