Ghirlandaio began work in country churches in the immediate vicinity of Florence, at Cercina and Brozzi, His guardians were the Vespucci, the most important family in his neighbourhood, whose most illustrious member was Amerigo, the great explorer. This family commissioned Ghirlandaio in 1471 to decorate their mortuary chapel in the church of Ognissanti in Florence. He devoted himself fully to painting in San Gimignano. (See in the next section.)

Preview	Picture Data	Info
	Apse fresco c. 1471 Fresco Parish Church of Sant'Andrea, Cercina
	St Barbara c. 1471 Fresco Parish Church of Sant'Andrea, Cercina
	St Jerome c. 1471 Fresco Parish Church of Sant'Andrea, Cercina
	St Antony c. 1471 Fresco Parish Church of Sant'Andrea, Cercina
	Madonna of Mercy and Lamentation c. 1472 Fresco Ognissanti, Florence
	Madonna of Mercy c. 1472 Fresco Ognissanti, Florence
	Lamentation over the Dead Christ c. 1472 Fresco Ognissanti, Florence
	Madonna and Child with St Sebastian and St Julian c. 1473 Fresco Sant'Andrea a Brozzi, San Donnino
	Baptism of Christ c. 1473 Fresco Sant'Andrea a Brozzi, San Donnino
	St Barbara Crushing her Infidel Father, with a Kneeling Donor c. 1473 Panel, 68 x 47 cm Private collection
	Madonna and Child 1470-75 Tempera on panel, 71 x 49 cm National Gallery of Art, Washington